SHANDONG LUXI ANIMAL MEDICINE SHARE LIMITED COMPANY

Amoxicillin Soluble Powder

Common name: Amoxicillin soluble powder

Description: White or off-white powder

Pharmacologic action:

Pharmacodynamics: Broad-spectrum semisynthetic penicillin, it exerts bacteriostatic effect by interfering with cell wall synthesis of bacterium. It is active against :  Bacillus coli, hemolytic streptococcus, Streptococcus pneumoniae, Staph ylococcus aureus, Hemophilus influenza, enterococci, salmonella, Bacillus typhi .

Pharmacokinetics: Administration by oral route, it is absorbed quickly , 75%~90% Amoxicillin are absorbed at the stomach and intestine, it is widespread distribute at Tissue and Body Fluid, can permeate placental barrier , microamount is distribute at milk, sweat and tear. plasma protein binding is 13%, half-life is 11.3 hours , 24~33% Amoxicillin are metabolism at liver, 45~68% are excreted by urine in original form, also part of it are excreted by biliary tract .the Pharmacokinetics parameter of administration by oral route to swine(10mg/kg): peak time 1.9h and 3.6h, peak concentration 1.6 and 0.8 mg/L, bioavailability 33% and 28%, mean residence time 8.7h and 10.4h.

Drug interactions: 1. Bacterium have cross resistance to Amoxicillin and ampicillin.  2. Probenecid Competitive inhibit tubular secretion, if be used with the product ,can increase the plasma concentration and extent the half-life of Amoxicillin. 3. Chlormycetin, macrolides, sulfamido and tetracyclines interfere the antibacterial action of Amoxicillin.

Indications: Antibiotics. Treatment of Gram-positive bacteria infection and Gram-negative bacteria infection sensitive to penicillin.